Übersicht

Leistungsverzeichnis

Quantitative Analyse:

• Bestimmung von Medikamenten, Metaboliten und körpereigenen Substanzen sowie körperfremden organischen Molekülen (zB Gifte oder Rückstände) in verschiedensten biologischen Matrices (Plasma, Urin, Gewebe, CSF...)
• Methodenentwicklung und -validierung (HPLC-MS/MS, HPLC-UV, HPLC-FL, HPLC-ELSD, enantioselektive Trennungen), Erfahrung mit hunderten Stoffen bisher
• GLP-Studien (Analytik) präklinisch/toxikologisch (Multi-Site-Studien)
• GCP-Studien (Analytik) klinisch/human
• GMP-Kontrollanalytik für Freigaben
• Nachweis von PEGylierten Substanzen in Plasma, CSF und Produktionsproben (FDP, FC, BDS)

Metabolitenidentifizierung

• Suche und Identifizierung von Metaboliten, Neben- und Abbauprodukten in biologischen Matrices, Produktionsproben und Formulierungen mit Orbitrap XL
• Synthese von Metaboliten semipräparativ

Verwendete Geräte

• HPLC-MS/MS: API6500 Q-Trap, API5000
• HPLC-MS: Orbitrap XL (hohe Massenauflösung und hohe Massengenauigkeit)
• HPLC mit konventionellen Detektoren: UV, Fluoreszenz, ELSD

Analyten

Acebutolol (S)  Acetylcarnitine (P)  N-Acetylcysteine (P)  N-Acetylneuraminic acid (P)  Acyclovir (P;U)  Acylcarnitines (P;U)  Allopurinol (P)  Amanitin (P)  Ambroxol (P)  Amiloride (P;U)  Amino acids (P)  Aminobutyric acid (S)  Amitriptylin and its N-oxide (P)  Amobarbital (P)  Amoxicillin (P)  Amphetamine (P)  Amphotericin B (R)  Ampicillin (P)  Anabolic steroids (B)  Antiasthmatic drugs (P;S)  Azelaic Acid (P)  Bacitracin (P)  Bendroflumethiazide (P)  Benzbromarone (P)  Benzodiazepines (various) (P;U)  Benzoic acid (S;P)  Benzyl alcohol (P)  Betahistine and 2-pyridylacetic acid (U;P)  Bezafibrate (P;U)  Budesonide (S;P)  Budipine and metabolites (P)  Busulfan (P)  Butizide (P)  Butorphanol and metabolites (P)  Caffeine (P)  Caffeinemetabolites (AFMU;17U;1X;1U)(U)  Canrenone (P)  Captopril (P)  Carbamazepine and carbamazepine-10;11-epoxide (P; W)  Carnitine (P; U; T)  Carrageen; Carvedilol (P)  Carvone (P; U)  Ceftizoxime (P; T)  Ceftriaxone (P; CSF)  Ceramides (P)  Cetylpyridiniumchloride (Saliva)  Chlormadinone acetate (P)  Chlorphentermine (P)  Chlortetracycline and 4-epi-chlortetracycline (F)  Chlorthalidone (B)  Ciclesonide and metabolite M1 (P; S; T)  Cimetidine (P) ;Cinnarizine (P)  Clarithromycin and 14-OH-clarithromycin (P; T)  Clavulanic acid (P)  Clenbuterol (U)  E- and Z-Clomiphene (P)  Clomipramine (P)  Clonidine (P)  Codeine (P)  Deanol (dimethylaminoethanol) (P; U)  Deoxycholate (R)  Desalkylflurazepam (P)  Desmosin (U)  Desmethylselegeline (P)  Dextromethorphan (P; U)  Dextrorphan and 3-hydroxymorphinan (P; U; CSF)  Diethylaminoethanol (P; U)  Diazepam (P)  Diclofenac (P; T; Syn; D)  Dihydralazine (P)  Dimetindene and metabolites (U)  Diphenhydramine (P)  Dipyridamole (P)  Doxorubicine (P)  Doxycycline (P)  Dronabinole (P)  Duramycin (P; U; T)  Enoxacin (P)  Erythromycin (P)  Escine (P)  Esomeprazole (P)  Estradiol (P)

Estriol (P)  Estrone (P) ;Ethanol (P)  Ethinylestradiol (P)  Ethosuximide (P)  Etoposide (P)  Fatty acids (P; CSF)  Flavonols (P; U)  Flunitrazepam (P)  Fluorine (P; U)  5-Fluorouracil (P)  Flurazepam and metabolites (P)  Flurbiprofen (P)  Fluspirilene (P)  Fluticasone propionate (P)  Folinic acid and 5-methyltetrahydrofolate ; (5-MTHF) (P)  Formoterol (P; S)  Fucoidans (P)  Furosemide (P; U)  GABA (-aminobutyric acid) (P)  Galloylquinic acid (P)  Gb1 + lyso-Gb1 (S; P; B)  Gb3 + lyso-Gb3 (S; P; U)  Gentamicin (R) ; Glibenclamide (P)  Gliclazide (P)  18-β-Glycyrrhetinic acid (P)  Hepes (R)  Homovanillic acid (HVA) (P; U) Hydrochlorothiazide (P; U)  Hydroxyethylflurazepam (P)  5-Hydroxyindoleacetic acid (5-HIAA) (P; U)  3-Hydroxymorphinan (P)  (3-Hydroxypropyl)mercapturic acid (3-HPMA) (P;U)  Hydroxytriamterene sulphate (P; U)  Hypericin and pseudohypericin (P)  Ibuprofen enantiomers (P)  Imipramine (P)  Indometacin (P; Syn)  Iodide (P; S)  Isosorbide-5-mononitrate (P)  Itraconazole (P)  Ketoconazole (P)  Ketoprofen (P)  Lansoprazole (P)  Levodopa (P)  Lofepramine and desmethylimipramine (P)  Lornoxicam (P)  Medazepam (P)  Mefenamic acid (P)  Menthol (U; P)  6-Mercaptopurine (P)  Metformin (P;U)  Methamphetamine (P)  Methoin (P)  Methotrexate (P; U)  5-Methoxypsoralen (P)  8-Methoxypsoralen (P)  Metoprolol enantiomers (P)  Metronidazole (P; T)  idazolam and metabolites (P)  Midodrine and metabolites (enantiomers) (P)  Minocycline (P)  Mitomycin C (P)  Molsidomine (P)  Montelukast (P)  Morphine (P)  Nabilone (P)  Naftidrofuryl (P)  Neomycin (P; R)  Nicorandil (P)  Nifedipine (P)  Nitrofurantoin (P)  Nordeprenyl (P)  Norfloxacin (P; U)  Omeprazole (P)  Orlistate (P)  Orphenadrine (P)  Oxazepam (P; U)  Oxipurinol (P)  Oxytetracycline (milk)  Paclitaxel (P; T)  Pantoprazole and metabolites (P)  Paracetamol (P)  Paroxetine (P)

PEGs (P; S)  Penicillin G (P)  Penicillin V (P)  Pentoxyfylline and metabolites (P)  Peptides (different) (P; U)  Peptide FX-06 (P)  Perphenazine (P)  Phendimetrazine (P)  Phenobarbital (P)  Phensuximide (P)  Phentermine (P)  Phenylbutazone and oxyphenbutazone (P)  Phenylbutyric acid (S; P)  Phenytoin (P)  Pimelic acid (P)  Piracetam (P)  Pirenzepine (P)  Ziroxicam (P)  Prazosin (P)  8-Prenylnaringenin (P; U; beer)  Primidone (P)  Procaine and 2 metabolites (P)  Promethazine (P)  Propafenone (P)  Propranolol (P)  Propyphenazone (P)  Prostaglandines (various) (P; T)  Pyridoxal (P)  Ranitidine (P)  Roflumilast and metabolites (P; U)  Salbutamol (P)  Salmeterol (P)  Salicylic acid (P)  Secobarbital (P)  Selegiline (P)  (see Desmethylselegiline; Amphetamine; Methamphetamine)  Serotonin (P)  Sertindole (P)  Silibinin and isosilibinin; (with diastereomeric separation) (P)  Sitosterol (P)  r-SPC (lung surfactant protein) (P)  Spironolactone (P)  Sulfamethoxazole (P)  Sulphadiazine (F)  Tamoxifen (P)  Temazepam (P)  Terconazole (P)  Tetracyclines (P)  Theobromine (P)  Theophylline (P)  Thiamine (P)  Thiols (P; S; U)  Thioridazine (P)  Thyreostatic substances (F)  Tiamulin (F; milk; P)  Tolafentrine (P)  Tolperisone enantiomers (P; U)  Tolperisone and metabolites (P; U)  Tramadol (P)  Triamterene (P; U)  Trimethoprim (P; F)  Tryptamine (P)  Tryptophan (P)  Tyramine (P)  Tyrosine (P)  Valnemulin (P;T; milk; F)  Valproic acid (P)  Vanillylmandelic acid (VMA) (P; U)  Verapamil and norverapamil (P) (also with enantiomeric separation)  Vitamin A (P)  Vitamin B1 (P)  Vitamin B2 (P)  Vitamin B6 (see pyridoxal) (P)  Vitamin E (P)  Doxorubicinol  Doxorubicinone  PEG  PEGylierte Substanz  PEGylated Substance

Zulassungen

GLP Zertifizierung für

• Analysen von menschlichen und tierischen Körperflüssigkeiten (z.B. Plasma, Serum, Harn) mittels HPLC(-MS/MS) Methoden bezüglich Wirkstoffgehalt an Arzneimitteln
• Analysen von Arzneimitteln und -stoffen mittels HPLC(-MS/MS) Methoden bezüglich Gehalt an Wirk- und Hilfsstoffen sowie Identifizierung von Abbauprodukten
• Analysen von Formulierungen für präklinische Studien mittels HPLC(-MS/MS) Methoden bezüglich Gehalt an Wirk- und Hilfsstoffen
  GMP Zertifizierung als „chemisch/physikalisches Qualitätskontrolllabor“

Referenzen

Referenzen geben wir gerne auf Anfrage

Ansprechpartner

Herr MMag. Klaus Mascher (CEO and Head of Marketing)
E-Mail: klaus.mascher@pharm-analyt.com

Herr Dr. Daniel Mascher (COO and Head of Analytics)
E-Mail: daniel.mascher@pharm-analyt.com