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Donnerstag, 17. Juni 2021
 
 
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Postdoc in Spatial Genomics m/w/d Aufrufe: 60

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Eingetragen am 10.06.2021
Einsatzort Heidelberg

Jobbeschreibung Job description:
The laboratory of Dr. Moritz Gerstung (Division of Artificial Intelligence in Oncoclogy) at the German Cancer Research Center (DKFZ) is looking for a postdoctoral fellow in spatial genomics. The group studies cancer evolution using a combination of AI analysis and new experimental technologies. We have recently co-developed experimental protocols to detect mutations in tissue sections which map how cancers have grown in their tissue context. This method, termed base specific in situ sequencing (BaSISS) extends the Cartana/10x ISS protocol. The BaSISS protocol combines sequencing of a tumour to identify mutations and localises these variants in a tumour section with single molecule padlock probes, which are interrogated by cyclic fluorescence microscopy. This generates signals from 100,000s of cells in a tissue, which are assembled into maps of subclonal growth. The protocols also allow for measuring the histopathological and transcriptomic changes acquired during tumour progression.

We are looking for an experimental postdoc to implement and run these spatial genomics and transcriptomics technologies in our new lab at DKFZ which will open in September 2021.

Your responsibilities:
- Implement and run BaSISS and general ISS experiments
- Run 10x visium spatial transcriptomics arrays on fresh and fixed tissues
- Implement other standard in situ hybridisation assays (e.g. RNAscope, Nanostring GeoMx) widely utilized in the field
Qualifikationen Key skills:
- A PhD in biological sciences or related field, with a focus on histology
- Advanced experience with tissue preservation (e.g. fixation, cryo-preservation) and sectioning including both paraffin embedded and frozen tissue material
- Experience in fluorescence microscopy of cells or tissues
- A proven track record of delivering ambitious biomedical research projects
- Excellent communication skills and ability to work effectively within a team

Desirable skills:
- Experience with immunohistochemistry and in situ hybridization
- Knowledge of image data pre-processing
- Ability to test, implement and troubleshoot new techniques and protocols
- Attention to detail and record keeping for sample and experimental tracking
Firma Deutsches Krebsforschungszentrum
69120 Heidelberg
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